Human Airway Eosinophils Exhibit Preferential Reduction in STAT Signaling Capacity and Increased CISH Expression

Capacity and Increased CISH Expression Preferential Reduction in STAT Signaling Human Airway Eosinophils Exhibit

Interleukin - S Signaling in Human Eosinophils Involves JAK 2 Tyrosine Kinase and Stat

Signaling by a wide variety of cytokines, including interferons, interleukins, and growth factors, involves activation of JAK kinases and Stat (Signal transducers and activators of transcription) proteins. At present, not much is known about the molecular mechanisms by which interleukin-5 (IL-5) exerts its diverse biologic effects. Human eosinophils are one of the most important target cells fo...

Protein Translation and Signaling in Human Eosinophils

We have recently reported that, unlike IL-5 and GM-CSF, IL-3 induces increased translation of a subset of mRNAs. In addition, we have demonstrated that Pin1 controls the activity of mRNA binding proteins, leading to enhanced mRNA stability, GM-CSF protein production and prolonged eosinophil (EOS) survival. In this review, discussion will include an overview of cap-dependent protein translation ...

Tissue factor expression, regulation, and signaling in human airway cells

TISSUE FACTOR EXPRESSION, REGULATION, AND SIGNALING IN HUMAN AIRWAY CELLS By Michael Denning Davis, RRT, Ph.D. A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy of Physiology and Biophysics at Virginia Commonwealth University. Virginia Commonwealth University, 2017 Advisor: Bruce K. Rubin, M.Engr., M.D., M.B.A., FRCPC Jessie Ball DuPont D...

JAK-STAT signaling in human disease

The past two decades have witnessed a dramatic increase in the prevalence of asthma worldwide (1). Asthma is a chronic disease characterized by variable airway obstruction, airway hyperresponsiveness (AHR), and airway inflammation and remodeling. Histological studies show that airways of asthmatic patients contain a chronic inflammatory infiltrate composed of lymphocytes, eosinophils, and mast ...